Bio 113 Portfolio
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  • Prion
    • Life Cycles
    • Evolutionary History
    • Kuru
    • Sources
  • Virus
    • Life Cycles
    • Evolutionary History
    • Rabies
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  • Bacteria
    • Life Cycles
    • Evolutionary History
    • Pseudomonas syringae
    • Borrelia burgdorferi
    • Sources
  • Archaea
    • Life Cycles
    • Evolutionary History
    • Sulpholobus acidocaldarius
    • Sources
  • Protista
    • Life Cycles
    • Evolutionary History
    • Giardia lamblia
    • Phytophthora infestans
    • Hexacontium enthacanthum
    • Corallina officinalis
    • Discostelium discoideum
    • Sources
  • Plantae
    • Life Cycles
    • Evolutionary History
    • Dicranum polysetum
    • Adiantum aleuticum
    • Ginkgo biloba
    • Pyrus communis
    • Magnolia virginiana
    • Sources
  • Fungi
    • Life Cycles
    • Evolutionary History
    • Lentinula edodes
    • Neurospora crassa
    • Gigaspora gigantea
    • Rhizopus stolonifer
    • Batrachochytrium dendrobatidis
    • Sources
  • Animalia
    • Life Cycles
    • Evolutionary History
    • Euplectella aspergillum
    • Lingula anatina
    • Priapulus caudatus
    • Mellita quinquiesperforata
    • Tachyglossus aculeatus
    • Sources

Life Cycles

pic (14)

Reproduction: (6)
  • Prions spread by transmitting a misfolded protein state
  • When a prion enters a healthy organism, it causes the existing properly folded proteins to convert to the disease-associated prion form
  • To do this, the prion acts as a template to misfold more proteins
  • In turn, each newly formed prion goes on to convert more proteins itself
  • This triggers a chain reaction that produces large amounts of the prion form
Picture
 Pathology:
Pic is (15)
  • Diseases caused by prions are called transmissible spongiform encephalopathies (TSEs) which are always fatal (2)
  • Characteristic of infection include: loss of motor control, dementia, paralysis, encephalitis, widespread neuronal loss (2)
  • The prion altered protein structure is extremely stable and accumulates in infected tissues, causing tissue damage and cell death (8)
  • The stable structure of prions makes them hard to eliminate with chemical and physical agents, making it hard to dispose of or contain them (8)
  • The main part of the brain affected by the Kuru prion is the Cerebellum (6)


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